Health and Racial Disparities in Diabetes Mellitus Prevalence, Management, Policies, and Outcomes in the United States (2024)

Introduction

Diabetes Mellitus (DM) is a severe and chronic metabolic disorder characterized by hyperglycaemia and various complications, including cardiovascular disease. Globally, the prevalence of diabetes in the general population is projected to escalate to 643 million by 2030 and 783 million by 2045 [3]. DM results from glucose dysregulation, with type 2 DM comprising 90% to 95% of cases among American populations, while type 1 DM accounts for 5% to 10% [4]. In type 1 diabetes, individuals produce insufficient or no insulin due to the destruction of insulin-producing cells by the body’s immune system. This condition is characterized as an autoimmune disease [5]. On the other hand, in type 2 diabetes, the body initially may produce adequate insulin, but it becomes less responsive over time. As the disease progresses, the pancreas gradually loses its capacity to generate sufficient insulin. Type 2 diabetes is linked to both genetic predisposition and lifestyle factors such as excessive weight or obesity, unhealthy dietary habits, and insufficient physical activity [6,7].

Scientific evidence underscores that diabetes significantly impacts quality of life, increasing the risk of adverse complications such as stroke, amputation, kidney failure, myocardial infarctions, and blindness, leading to substantial morbidity and premature mortality [8-10]. Interestingly, the overall rate of diabetes-related complications has decreased since 1990 due to advancements in early detection, screening, diagnosis, and treatment. However, minority patients with diabetes continue to experience these complications at a disproportionately higher rate compared to nonHispanic White patients. Moreover, they are less likely to receive recommended diabetes preventive care, including haemoglobin A1c (HbA1c) testing, annual cholesterol screening, and retinal examinations [11]. We focus mainly on type 2 DM in this review paper.

The overarching objective of this review article is to comprehensively address racial disparities in DM within the United States, focusing on prevalence rates, management strategies, policies, and health outcomes across diverse ethnic groups.

Approaches

Data Sources and Data Extraction

We undertook a comprehensive systematic review and metaanalysis, drawing on data sourced from nationally representative surveys, healthcare databases, clinical trials, and published literature covering the period from 2014 to 2023. This review was performed using seven databases: Science Direct, PubMed Central, MEDLINE, Google Scholar, World Health Organization (WHO), Food and Drug Administration (FDA), and Centers for Disease Control and Prevention (CDC). Our search incorporated key terms such as “Diabetes Mellitus (DM)”, “racial disparity”, “prevalence”, “management”, “policies”, and “outcomes”.

Selection criteria were limited to peer-reviewed articles with titles and abstracts explicitly addressing these key terms.

The systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure transparency and reproducibility. Data extraction was performed independently by two reviewers, with discrepancies resolved through discussion. The quality of included studies was assessed using the Cochrane risk-of-bias tool for randomized trials and the Newcastle-Ottawa Scale for observational studies.

Results and Discussions

We found several peer-reviewed articles that addressed the racial disparities in DM prevalence, management, policies, and outcomes. Our findings highlight significant racial disparities in diabetes prevalence, with minority populations, including African Americans, Hispanics, and Native Americans, consistently exhibiting higher rates than their Caucasian counterparts. Beyond prevalence, disparities extend to access to healthcare resources, diabetes education, and preventive measures. Additionally, challenges in diabetes management, including accessing optimal treatment modalities, medication adherence, and diabetes selfmanagement education, are identified among minority populations. Socioeconomic factors, particularly income and education, emerge as significant contributors to these disparities. In our results and discussion sections, we did not summarize all the racial disparities in DM prevalence, management, and outcomes examined in each study. However, we highlighted their main findings in the present article. These are discussed in more detail in subsequent sections below.

Racial and Ethnic Disparities in Diabetes Mellitus

Diabetes mellitus (DM) has a disproportionately higher impact on minority communities in the United States (US). Presently, 13% of the general adult population in the US has diabetes. Figure 1 illustrates the notable variation in diabetes prevalence among racial and ethnic groups in the US. The data informing the graph, as depicted in Figure 1, were sourced from the Centers for Disease Control and Prevention’s National Diabetes Statistics Report 2020 [12].

Figure 1:Diabetes diagnosis rates by racial and ethnic groups in the United States.

As seen in Figure 1, American Indians/Alaska Natives exhibit a disproportionately high rate at 14.7%, followed by Hispanics at 12.5%, and non-Hispanic Blacks at 11.7%. In contrast, lower rates are observed among non-Hispanic Asians at 9.2% and nonHispanic Whites at 7.5% (DHHS, 2020). Moreover, an estimated 38.0% (96 million) of adults aged 18 and above have prediabetes, as per the National Diabetes Statistics Report 2020. Alarmingly, more than 8 in 10 individuals with prediabetes are unaware of their condition [13]. A recent study indicated a 33% increase in diabetes-related deaths during the COVID-19 pandemic, with twothirds attributed to SARS-CoV-2 infection. Additionally, this study highlighted a rise in diabetes-related mortality, particularly among young adults, and widened disparities across age, sex, and racial and ethnic subpopulations [14].

In the US, the incidence of type 2 diabetes among children and adolescents aged 10 to 19 years has risen gradually from 2002 to 2015 [15,16]. However, when broken down by race and ethnicity, the incidence remained stable among non-Hispanic white individuals but surged significantly among all other racial and ethnic groups, with particularly marked increases observed in nonHispanic Black children and adolescents [16].

Epidemiological Data on Diabetes Mellitus

Epidemiological data on DM comprehensively explain its prevalence, trends, and demographic disparities. Major key findings of epidemiological studies into DM are detailed in the sections below.

Prevalence, Trends, and Projection of Diabetes Mellitus: Over the years, the trends in DM prevalence have been steadily increasing, reflecting a growing public health concern. In 2021, crude estimates revealed that 38.4 million individuals, comprising 11.6% of the population of all ages, were affected by diabetes. Among adults aged 18 years or older, 38.1 million adults, accounting for 14.7% of all US adults were diagnosed with diabetes. Over the period of 2001 to 2020, the age-adjusted prevalence of total diabetes significantly increased among US adults, rising from 10.3% in 2001-2004 to 13.2% in 2017-2020 [17]. Future projections from a recent study indicate a notable uptick in diagnosed diabetes cases, with an estimated 39.7 million adults affected by 2030 and 60.6 million by 2060 [18]. Additionally, the study forecasts a rise in the prevalence rates across all race-sex groups, highlighting that Black women and men are anticipated to have the highest prevalence [18].

Demographic Disparities of Diabetes Mellitus: Diabetes mellitus (DM) affects different population groups unevenly, with specific demographics experiencing higher rates of the condition.

Within the Hispanic population, Mexican American adults exhibited the highest age-adjusted prevalence of diagnosed diabetes at 13.4%, followed by 12.4% in Puerto Rican-American adults. In comparison, Cuban American adults had the lowest prevalence at 6.5% [19]. Recent studies have highlighted the heterogeneity in diabetes prevalence and risk factors among Hispanic subgroups [20,21].

Among Black populations, studies have shown differences between US-born and African-born or Caribbean-born adults, with higher prevalence rates observed among US-born individuals in some instances [22]. However, other studies suggest varying trends, indicating complexities within this population. Acculturation and time spent in the US. also influence diabetes risk among foreignborn Blacks [22].

Diabetes rates among Asian Americans vary, with Filipino and Korean Americans exhibiting higher prevalence rates. The CDC’s data indicate varying prevalence rates among different Asian subgroups, with Filipino and Asian Indian populations showing higher rates compared to other Asian groups [13].

As another minority group in the United States, American Indians also experience a disproportionate prevalence of DM within their communities which is closely tied to economic disparities. Factors such as high neighborhood poverty rates, limited access to healthcare services, and enduring economic challenges contribute to this burden. These circumstances often lead to unhealthy lifestyle practices that exacerbate the development and management of chronic illnesses like diabetes. Furthermore, discrimination, especially within healthcare settings, has been identified as a contributing factor to the heightened prevalence of diabetes [19].

Undiagnosed Cases of Diabetes Mellitus

A significant proportion of individuals with DM remain undiagnosed in the US, which has implications for disease management and prevention of complications. Interestingly, epidemiological studies have identified a substantial case of undiagnosed diabetes until clinically apparent, necessitating an understanding of undiagnosed cases. Scientific studies highlight a substantial burden of undiagnosed diabetes, with estimates indicating 8.7 million undiagnosed cases in the US, constituting 22.8% of all adults with diabetes [23,24]. However, a recent study suggests a lower prevalence of undiagnosed DM, employing a two-test criterion for screening [24,25]. In addition, several epidemiological studies have identified higher prevalence rates among older adults, obese individuals, and certain racial and ethnic groups, including Mexican and Asian Americans, and those without healthcare access [26,27]. Specifically, Mexican Americans exhibit significantly higher rates of undiagnosed diabetes compared to non-Hispanic whites, as do Asian Americans [24].

Socioeconomic Disparities in Diabetes Mellitus

Diabetes mellitus (DM) burdens the US population unevenly, with varying rates across socioeconomic statuses (SES), and racial, and ethnic groups. SES, a complex construct including factors like education and income, strongly predicts DM onset and progression [28].

Low Income and Poverty Associated with Diabetes Mellitus Disparity: Lower income levels are associated with a higher prevalence of DM. Poverty often limits access to healthy food options, safe environments for physical activity, and healthcare services, leading to higher rates of obesity and diabetes within impoverished communities. The low-income population bears a disproportionate burden of DM [29,30]. Numerous studies highlight income as a significant contributor to diabetes disparities [15,31,32]. A previous study reported a surge in diabetes prevalence among middle-income, near-poor, and poor adults between 2011 and 2014 [15]. A recent investigation observed higher diabetes prevalence in low-income communities from 2001 to 2018, with income emerging as the primary driver of diabetes disparities, especially among middle-aged females [32]. This inequality has widened since 2011, potentially due to limited opportunities for preventive screenings, food insecurity, and sedentary lifestyles in low-income areas [33]. Poor minorities are likely to eat unhealthy diets. As a result, unhealthy diet and sedentary habits elevate obesity risk, a known diabetes factor [34,35]. Racial and ethnic minorities face heightened diabetes risk, primarily due to socioeconomic factors. Income-related inequality largely underpins this disparity [31]. Hispanics and non-Hispanic Blacks, often impoverished compared to Whites, face higher diabetes susceptibility, compounded by obesity, food insecurity, and physical inactivity [36]. Addressing healthcare quality and access is crucial for mitigating diabetes disparities in these communities.

Poverty is also a commonly found phenomenon among oppressed or indigenous populations [37]. Studies have confirmed that poverty is associated with the development and complications of type 2 diabetes in adults [33,29]. One study investigated poverty as a risk factor for developing type 2 diabetes in youth and discovered that low family income was associated with a significantly higher hazard of type 2 diabetes in adolescents compared to high family income. The dose-dependent association indicates that the risk of type 2 diabetes in adolescents increases with a decrease in household income 38. Furthermore, research revealed a significant link between children and adolescents from lower-income households and a higher risk of hospitalization for diabetes complications [38].

Scientific studies have been conducted to explore the relationship between neighborhood socioeconomic status and diabetes. For instance, Gaskin et al. studied how individual and neighborhood poverty interact to affect the likelihood of developing diabetes. Their findings revealed that poor adults living in nonpoor neighborhoods are more likely to have diabetes compared to nonpoor adults living in nonpoor neighborhoods [39]. Furthermore, the study found that poor adults living in poor neighborhoods have double the odds of having diabetes. The study also observed a gradient in the relationship between race, poverty, and place. When comparing the likelihood of having diabetes, poor Whites living in poor neighborhoods had the highest odds when compared to nonpoor Whites living in nonpoor neighborhoods (odds ratio [OR] 2.51, 95% CI = 1.31–4.81). Also, poor Blacks residing in poor neighborhoods and nonpoor Blacks living in poor neighborhoods had similar odds of having diabetes (OR 2.45, 95% CI 1.50–4.01 and OR 2.49, 95% CI 1.48–4.19, respectively). Lastly, poor Whites living in nonpoor neighborhoods had the lowest odds of having diabetes (OR 1.73, 95% CI 1.16–2.57) [39].

Moreover, studies have shown variations in diabetes prevalence across census tracks, attributable to the socioeconomic status of each neighborhood. Kolak, et al. discovered that Type 2 DM rates were notably higher in census tracts characterized by lower incomes, reduced high school graduation rates, increased singleparent households, and crowded housing [40]. Additionally, adults with prediabetes face an elevated risk of developing Type 2 DM if they reside in neighborhoods with lower educational attainment, diminished annual income, and a higher percentage of households receiving Supplemental Nutrition Assistance Program benefits [41].

The Centers for Disease Control and Prevention (CDC) indicated that individuals with a family income lower than the federal income poverty level often have the greatest prevalence of diabetes (Table 1) [42]. As seen in table 1, families with less than 100% federal poverty level have a higher incidence of diabetes.

Table 1: Diabetes Incidence Rates in US Adults Based on Family Income Level.

Education Level Associated with Diabetes Mellitus Disparity: Education provides individuals with knowledge about healthy lifestyle choices, access to resources, and the ability to navigate healthcare systems effectively. Higher levels of education are generally associated with better health outcomes, including a lower risk of developing diabetes. Education correlates closely with health, influencing diabetes mellitus prevalence and outcomes. Adults’ diabetes rates in the US vary by educational attainment, with the highest prevalence among those without a high school diploma [17]. Lower educational levels, poor diet, and race intertwine, contributing to diabetes disparities [43,44]. NonHispanic Blacks, Hispanics, and individuals with lower education exhibit higher diabetes incidence and complications [43,45]. Systemic and structural racism hampers educational opportunities for Black and Hispanic individuals, affecting health outcomes [46]. Higher education promotes healthy behaviors and better health outcomes, including DM management [47]. It fosters critical thinking, enabling individuals to navigate health information effectively [48]. Moreover, higher education correlates with better employment and healthcare access, ultimately improving health outcomes [49,50].

Based on the CDC’s 2019-2021 National Health Interview Survey, individuals lacking a high school education exhibit a higher propensity for diabetes than those with higher educational attainment [42]. However, limited research has studied the correlation between educational levels and the incidence of diabetes-related complications upon diagnosis. A study by Leahy et al. revealed a significant elevation in the risk of diabetes-related complications among patients with elementary school education compared to those with a university degree or higher [51]. Similarly, Kumar, et al., observed a marked decrease in the risk of diabetes-related complications among individuals with six years of formal education compared to those without any educational background [52]. Moreover, Liao et al., demonstrated that individuals with higher educational achievements are less prone to experiencing complications associated with diabetes at the time of diagnosis [53]. This can be attributed to their enhanced health literacy, facilitating earlier detection of disease-related issues and reducing complications upon diagnosis, potentially delaying the diagnosis.

Limited Access to Health Insurance and Healthcare Associated with Diabetes Mellitus Disparity

Health insurance plays a pivotal role in diabetes management.

Coverage facilitates diagnosis, treatment, and preventive care [54]. Under the Affordable Care Act, health insurance coverage increased, benefiting adults with DM [55,56]. Insured individuals with diabetes receive better care and have fewer complications than the uninsured [22]. However, racial and ethnic minorities historically face lower insurance rates, exacerbating diabetes disparities [57]. Insurance coverage significantly influences diabetes care quality [58]. Despite improvements, disparities persist, with minorities and women experiencing treatment gaps [58]. Uninsured individuals face challenges accessing diabetes screenings and care, leading to undiagnosed diabetes and poorer outcomes [13,59]. Tailored diabetes education programs, such as those for Hispanic populations, improve outcomes, underscoring the value of culturally sensitive intervention [60]. Promoting selfcare and culturally competent healthcare can enhance diabetes patients’ quality of life.

In a survey conducted between 2015 and 2016, significant disparities in the quality of diabetes care persisted between White individuals and minority groups. Additionally, factors such as lack of health insurance, lower educational attainment, and the presence of obesity and chronic kidney disease emerged as strong predictors of diabetes incidence and mortality among minority populations [61]. Furthermore, Kamat, et al., demonstrated that the prevalence of diabetes increased with lower education levels, and there was an upward trend in the percentage of Hispanics with diabetes over the study period [61]. These shifts could be attributed to inadequate insurance coverage, limited health knowledge, and subsequent suboptimal diabetes preventive care and management, particularly prevalent among Hispanic populations.

DM care remains a great challenge due to its complex interactions with multiple factors such as education, early screening, socioeconomic status, and the healthcare system [33,62]. It poses significant challenges to healthcare systems globally. Therefore, understanding the multifaceted factors associated with the prevalence and management of DM within healthcare systems is paramount for effective prevention and treatment strategies.

The healthcare system is crucial in-patient diabetes selfmanagement and care [63,64]. High-quality care for diabetes decreases the risk of diabetes complications and mortality [65,66]. According to the American Diabetes Association (ADA), it is recommended for diabetic patients with type 2 to frequently visit their healthcare providers to perform haemoglobin A1c tests, foot exams, dilated eyes exams, blood cholesterol tests, and flu vaccines [36]. Regular check-up and testing of HbA1C blood glucose is considered by the ADA as foundational care for patients with type 2 diabetes 1.

In the United States, diabetes care disparities in the healthcare system could be examined in terms of affordability, accessibility, and competency of healthcare workers [67]. In 2018, a scientific study used the category of health insurance coverage, whether private, public, or lack of health insurance, to measure the accessibility of diabetic patients to health [68]. It was noted that uninsured adults were significantly less likely to receive diabetic services compared to those with private while adjusting for possible confounding factors [68]. Furthermore, a populationbased study of diabetic patients in the US from 2005-2016 revealed that patients who had health insurance coverage had higher odds of seeking diabetic care and meeting the glycaemic targets set by the ADA compared to those who were uninsured [58]. They also reported a significantly lower odd ratio in NHB achieving the blood pressure, and cholesterol level compared to NHW [58]. Worldwide, patients in rural areas are often challenged with the accessibility to healthcare due to geographic isolation, shortage of healthcare workers, and lower health spending compared to urban areas [69].

An investigation found worse diabetic quality outcomes, low frequent visits for care, and less accessibility to specialist care in rural settings compared to urban areas [67]. In brief, high-quality diabetic management is associated with to social determinants of health and access to healthcare quality [33,70,71]. Therefore, an active interaction involving the patients, healthcare workforce, and health care system would be beneficial to delivering highquality care for diabetes [72,73]. Nevertheless, the healthcare system worldwide is struggling to improve the health of their population with constrained budgets. The gap between the resources’ availability and the diabetic care adversely impacts not only the treatment but also the health outcome [74]. Consequently, self-management training for diabetes, virtual care, and reducing barriers to access to healthcare have been recommended for diabetic patients [74]. Ensuring of funding on training programs are directed to meet the need for treatment and education on diabetes, to assign pre-deductible insurance coverage for high diabetic treatment, and to enhance patient safety policy in healthcare practice [74]. The system should also implement deploying new value-based approaches to reward financing or penalizing organizations and providers depending on the quality of care they provide.

Management of Diabetes Mellitus

The International Diabetes Federation (IDF) estimated approximately 463 million adults with diabetes in 2019, which is projected to increase to 578 million by 2030 and 700 million by 2045. Current treatment options for DM primarily involve antidiabetic drugs such as metformin, sulfonylurea, thiazolidinedione, or DPP4 inhibitors [75]. However, these medications often fall short of achieving complete diabetes control, necessitating the exploration of new therapeutic strategies to address the burden of the disease.

One such strategy, accessible and cost-effective for diabetic patients, involves the use of medicinal plants, vitamins, and essential elements. Recent research in our laboratory has highlighted the health benefits of edible medicinal plants such as Allium sativum, Momordica charantia, Hibiscus sabdariffa L., and Zingiber officinale, as well as vitamins C, D, and E, all of which exhibit antihypoglycemic properties and hold promise for the prevention and/ or management of DM [76]. It has been reported that the beneficial health effects of these edible medicinal plants and essential vitamins include their anti-inflammatory, immunomodulatory, cardioprotective, hypolipidemic, hypoglycaemic, antioxidant, antibiotic, antifungal, antimicrobial, antiseptic, anticancer, and antiviral activities [76-80].

Furthermore, incorporating physical activity into daily routines, along with other preventive measures like maintaining a healthy diet, can potentially lead to improved outcomes in managing DM. The World Health Organization (WHO) has pinpointed insufficient physical activity as a significant risk factor driving global mortality rates. Their guidelines stress that even modest levels of physical activity offer benefits over complete inactivity, and higher levels of activity correlate with even better health outcomes [81-83]. While nutritional and physical activity benefits are often studied separately, recent findings underscore the synergistic potential of integrating both to achieve stronger positive health effects and fortify the immune system [84,85]. This integrated approach surpasses the impacts of singular-focused strategies. Research indicates that maintaining a balanced diet and engaging in regular physical activity during childhood can significantly diminish the likelihood of developing chronic diseases in adulthood [86,87]. A balanced diet, characterized by ample intake of fruits, vegetables, whole grains, plant proteins, and dairy products, furnishes the body with vital nutrients crucial for optimal growth and development.

Figure 2 below provides an example of health promotion practices based on a healthy diet and physical activity that individuals are encouraged to adopt in their daily lives.

Figure 2: Achieve optimal health through consistent engagement in physical exercise and a well-balanced dietary regimen rich in nutrient-packed vegetables, fruits, and essential vitamins.

Addressing Diabetes Mellitus through Healthy Diet Strategies

Maintaining a well-balanced diet is pivotal in fostering a robust immune system, bolstering its ability to prevent diabetes mellitus effectively. Edible medicinal plants, known for their extensive historical use in traditional medicine to address many diseases, have emerged as promising sources of antidiabetic drugs. Edible medicinal plants and/or plant-based medicine have long been employed worldwide as cost-effective remedies for preventing and treating diabetes. Eating plant-based medicine plays an excellent and effective role in addressing diabetes mellitus through healthy diet strategies. Especially in economically disadvantaged regions, reliance on these natural resources is commonplace for managing various health conditions, including diabetes. Notably, many pharmaceuticals in use today are derived from compounds found in traditional medicinal plants. For instance, metformin, a widely prescribed anti-hyperglycaemic drug, traces its origins to the historical use of Galega officinalis in DM treatment [88,89]. Among the most prominent medicinal plants and vitamins with hypoglycaemic properties, aiding in immune system enhancement and blood sugar regulation in humans, are Allium sativum (garlic), Momordica charantia (bitter melon), Hibiscus sabdariffa L. (roselle plant), Zingiber officinale Rosc (ginger), as well as vitamins C, D, and E [76]. The accessibility, affordability, and efficacy of these edible medicinal plants render them pivotal in addressing DM management, particularly in resource-constrained settings across the globe.

Syzygium cumini, commonly known as Black Plum is a medicinal plant that merits attention. This fruit-bearing tree is native to India. In a rat experiment, Black Plum exhibited various beneficial effects, including regulating blood sugar levels and enhancing insulin sensitivity. Oral administration of ethanolic and aqueous extracts derived from the bark of Syzygium cumini (at a dosage of 500 mg/kg for 21 days) demonstrated notable reductions in blood glucose levels in diabetic Wistar rats [90].

The consumption of a healthy diet is a wonderful and strategic way to help address DM, but the patient’s body is very vital as well. That is why the edible medicinal way seems to be effective. To address the healthy diet, patients should be willing to change their eating habits. Minor lifestyle changes, especially healthy diet habits can help with this. Although sugar plays a big role in DM, research shows that fat is the issue when it comes to diabetic patients. Minimizing fat intake and reducing body fat help insulin do its job much better. Newer treatment programs drastically reduce meats, high-fat dairy products, and oils [91,92]. It is even stated that starting a vegan diet can also help by avoiding animal product foods. Animal products contain fat and are usually linked with heart disease as well as insulin resistance. It also affects cholesterol levels as well. Forty-three percent of the vegan group reduced their diabetes medications. Among those participants who didn’t change their lipid-lowering medications, the vegan group also had more substantial decreases in their total and LDL cholesterol levels [93]. Current scientific pieces of evidence indicate that adopting healthy dietary patterns can decrease the likelihood of developing major diet-related chronic diseases, including type 2 diabetes, cardiovascular disease, and certain cancers [94-96].

Diet is a crucial modifiable risk factor for the prevention of noncommunicable diseases, including obesity, Cardiovascular Disease (CVD), Type 2 diabetes (T2D), and certain cancers. Several systematic reviews and meta-analyses (SRMA) of Randomized Controlled Trials (RCT)have indicated that interventions aimed at improving diet quality (e.g., low-calorie and low-fat diets) and/or increasing physical activity levels can delay or prevent the onset of T2D [97,98]. However, this evidence primarily focuses on highrisk populations, such as individuals with prediabetes or obesity.

Increasing the consumption of fruits and vegetables among the US population is particularly important given the strong evidence that healthy dietary patterns rich in fruits and vegetables are associated with less long-term weight gain, whereas diets characterized by meat and fried foods are linked to greater weight gain [99]. A recent analysis of US health professionals highlighted that a 4-year weight change was positively and strongly associated with increased daily servings of potato chips, potatoes, Sugar-Sweetened Beverages (SSBs), unprocessed red meats, and processed meats [100]. Conversely, weight change was inversely associated with the intake of vegetables, whole grains, fruits, nuts, and yogurt [101]. In addition to specific foods, poor carbohydrate quality also appears to influence subsequent weight gain and T2D risk.

Addressing Diabetes Mellitus through Physical Activity Strategies

Physical exercise is of the utmost importance in dealing with diabetes. Daily exercise aids in the digestion of food and helps control blood sugar in diabetic patients [91]. Today, exercise is recommended as one of the first management strategies for patients newly diagnosed with diabetes mellitus and, together with diet and behavior modification, is a central component of diabetes mellitus and obesity prevention programs [102,103]. Notably, aerobic exercise is a well-established way to improve HbA1c, and strong evidence exists about the effects of aerobic activity on weight loss and the enhanced regulation of lipid and lipoprotein metabolism [102-104]. There are many more physical activity strategies that researchers can look at. For example, resistance training is necessary. Resistance Training (RT) is when you perform resistance exercises to strengthen and build muscle mass. RT can combat metabolic dysfunction in patients with type 2 diabetes It has the power to combat metabolic dysfunction in patients with type 2 diabetes It seems to effectively improve overall metabolic health and reduce metabolic risk factors in diabetic patients [105]. RT is one way rather than aerobics. It can help improve insulin sensitivity by helping the muscle cells uptake glucose, which can help lower blood sugar levels. This is important because it allows the glycaemic control for a diabetic.

Another physical activity would be Interval Training (IT). It is an exercise type where you alternate between intense and lower activities. For example, when you sprint for 10 minutes, slow down catch your breath, and then continue to sprint. This exercise is used to pace the patient’s body. Research has shown that HighIntensity Interval Training (HIIT) can promote improvements in glucose control and cardiovascular health in individuals with type 2 diabetes [106-108]. HIIT has had a major progression. When it discussed in patients with type 2 DM there have been signs of improvement in insulin sensitivity, blood pressure and cardiovascular, and metabolic health. Lastly, incorporating physical activity into the patient’s daily routine would be beneficial. For example, instead of taking the elevator, taking the stairs, or walking around the neighborhood when given a chance instead of lying on the couch. These little activities can go a long way. The key to addressing diabetes in physical activities is finding something you can integrate into your routine. Regular exercise produces health benefits beyond improvements in cardiovascular fitness. These include enhanced glycaemic control, insulin signaling, and blood lipids, as well as reduced low-grade inflammation, improved vascular function, and weight loss [104,109].

In a comprehensive report published by Health and Human Services, USA, it was reported in 2015 that physical activity significantly improved abnormal glucose tolerance primarily when caused by insulin resistance, rather than by a deficiency of circulating insulin [110]. Additionally, physical activity is likely most beneficial in preventing the progression of Type 2 Diabetes Mellitus (T2DM) during its early stages, before insulin therapy becomes necessary [111]. The protective mechanism of physical activity appears to have a synergistic effect with insulin. During a prolonged session of physical activity, contracting skeletal muscles enhance glucose uptake into the cells, increasing blood flow to the muscles and improving glucose transport into muscle cells [112]. Moreover, physical activity has been found to reduce intra-abdominal fat, a known risk factor for insulin resistance. Other studies have shown that physical activity is inversely associated with intra-abdominal fat distribution and can reduce overall body fat stores [113,114].

Treatment of Diabetes Mellitus

The treatment approach for Diabetes Mellitus (DM) varies depending on the specific type [114] diagnosed in a patient. Two main types, Type 1 Diabetes, and Type 2 Diabetes, have distinct characteristics and underlying causes. Type 1 Diabetes results from an autoimmune attack on the body’s insulin-producing cells and typically manifests from birth. Conversely, Type 2 Diabetes occurs when body cells develop insulin resistance, or the pancreas fails to produce sufficient insulin to meet the body’s needs.

Tailoring treatment for each type and individual involves considering various factors such as symptoms, the type of DM, and the patient’s financial resources or ability to make significant lifestyle changes. While lifestyle modifications have shown benefits, they can present long-term challenges for many patients. Physicians must be knowledgeable about the range of pharmaceutical options available for diabetes treatment and select the most effective, safe, and tolerable medications for their patients [115].

Treatment modalities for DM encompass both oral and injectable medications. For Type 2 DM, numerous oral pharmacological agents exist, including sulfonylureas, meglitinides, metformin, thiazolidinediones (TZDs), alpha-glucosidase inhibitors, dipeptidyl peptidase IV (DPP-4) inhibitors, bile acid sequestrants, dopamine agonists, sodium-glucose transport protein 2 (SGLT2) inhibitors, and oral glucagon-like peptide 1 (GLP-1) receptor agonists. Additionally, injectable GLP-1 agonists are used to lower blood sugar levels in individuals with type 2 DM by stimulating insulin secretion and suppressing glucagon secretion.

In contrast, Type 1 DM requires a different treatment approach due to its autoimmune nature, which destroys insulin-producing β cells. Insulin replacement therapy stands as the primary treatment option for type 1 DM 116. This therapy helps regulate blood sugar levels and enhance the quality of life for patients. In cases of Diabetic Ketoacidosis, a life-threatening condition caused by severe insulin deficiency, intensive insulin therapy becomes crucial.

Management of type 1 DM often involves a combination of intensive dietary control and lifelong exogenous insulin supplementation, administered either through multiple daily injections or insulin pumps [116]. In some cases, transplantation becomes a consideration, with pancreas or islet cell transplants being options for adult patients with type 1 DM [117]. However, these procedures are less common in pediatric or child patients. Dietary modifications and regular physical activity serve as fundamental components of diabetes treatment, aiding in energy balance and overall management of the condition [115].

Policy and Advocacy Addressing Diabetes Mellitus

Diabetes ranks among the top 10 causes of mortality worldwide. Alongside cardiovascular disease, cancer, and respiratory diseases, these ailments contribute to more than 80% of premature deaths from noncommunicable diseases [118]. Those with diabetes face a 2-3 times higher risk of all-cause mortality [119]. Moreover, the presence of diabetes correlates with heightened mortality rates from infections, cardiovascular disease, stroke, chronic kidney disease, chronic liver disease, and cancer [120].

A holistic strategy, integrating public awareness, preventive measures, healthcare access, research, and collaboration, is indispensable in tackling the intricate challenges posed by DM through policy and advocacy endeavors. Figure 3 illustrates a structured framework to address DM epidemic effort comprehensively.